Resource Type

Journal Article 190

Conference Videos 1

Year

2024 1

2023 13

2022 14

2021 22

2020 12

2019 16

2018 15

2017 14

2016 9

2015 9

2014 9

2013 7

2012 5

2011 4

2010 3

2009 5

2008 7

2007 8

2006 3

2005 2

open ︾

Keywords

immunotherapy 7

COVID-19 4

immune checkpoint inhibitor 4

PD-L1 3

Adverse geology 2

Anti-inflammation 2

PD-1 2

Traditional Chinese medicine 2

chimeric antigen receptor T cell 2

hypoxia 2

immune escape 2

immune response 2

lung cancer 2

resistance 2

β 1

-catenin 1

3D induced polarization 1

3D printing 1

3D seismic method 1

open ︾

Search scope:

排序： Display mode:

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-relatedadverse events (irAEs) in almost all organs or systems.

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

HTML PDF Collect

Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneAlong with the characterization of more immune checkpoints, the combinatory treatment of multi-immunecheckpoints and their related inhibitors, and discusses the advantages of combination therapy, as wellas the risk of immune-related adverse events.

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

HTML PDF Collect

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Results showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was relatedmutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was relatedAs for immunity, FGF13 was remarkably associated with T cell count, immune checkpoint genes, and cytokinesOverall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

HTML PDF Collect

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverserespiratory events in post anesthesia care unit

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 189-195 doi: 10.1007/s11684-017-0533-8

Abstract: are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverserespiratory events in the post anesthesia care unit (PACU).Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with highAge, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratoryevents in the PACU.

Keywords： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

HTML PDF Collect

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 20-31 doi: 10.1007/s11684-016-0493-4

Abstract: Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as

Keywords： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

HTML PDF Collect

Smoothing ramp events in wind farm based on dynamic programming in energy internet

Jiang LI, Guodong LIU, Shuo ZHANG

Frontiers in Energy 2018, Volume 12, Issue 4,   Pages 550-559 doi: 10.1007/s11708-018-0593-8

Abstract: When wind power is integrated into the main grid, ramp events caused by stochastic wind power fluctuationThis paper proposes a dynamic programming method in smoothing ramp events.that the dynamic programming method proposed is effective for smoothing wind power and reducing ramp events

Keywords： energy internet     wind power     ramp events     dynamic programming    

HTML PDF Collect

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Frontiers in Energy 2023, Volume 17, Issue 1,   Pages 1-4 doi: 10.1007/s11708-023-0869-5

Abstract: . {{custom_ra.content}} . . . {{article.highlightEn}} . . . {{article.abstractEn}} . . . {{article.authorSummayEn}} .
HTML PDF Collect

The Ejection and Sweep in the Wall Region of a Turbulent Boundary Layer Under Adverse Pressure Gradient

Zhang Qiang,Lu Lipeng

Strategic Study of CAE 2003, Volume 5, Issue 11,   Pages 47-50

Abstract:

The evolution of coherent structures in the wall region of a turbulent boundary layer under adversethat to the shear stress, the contribution of sweep motions is stronger than that of ejections under adversethe transport of shear-stress and kinetic energy of turbulence more strongly than the ejections under adverse

Keywords： coherent structures     turbulent boundary layer     adverse pressure gradients     direct numerical simulation    

HTML PDF Collect

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 277-284 doi: 10.1007/s11684-018-0630-3

Abstract: The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa valuesDrug-likeness screening was further conducted to obtain the candidates that significantly reduced the adverse

Keywords： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

HTML PDF Collect

The effects of festivals and special events on city image design

LIU Yuan, CHEN Chong

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2,   Pages 255-259 doi: 10.1007/s11709-007-0032-0

Abstract: On the analysis of the important roles of events and city image in the context of city marketing, thispaper suggests that holding festivals or special events is an effective approach to enhance city marketingThe positive impacts of festivals and special events, such as the identification of city image, the promotionThe negative impacts of festivals and special events are also talked about.Identity, the City Visual Identity and the City Behavior Identity concerned with festivals and special events

Keywords： Visual Identity     reversal     transmission     marketing     Behavior Identity    

HTML PDF Collect

Characterization of bacterial communities during persistent fog and haze events in the Qingdao coastal

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-020-1334-x

Abstract:

• Light haze had little effect on bacterial communities.

Keywords： Bacterial community     Persistent fog and haze     Particle size    

HTML PDF Collect

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

HTML PDF Collect

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

HTML PDF Collect

Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

HTML PDF Collect

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

HTML PDF Collect

Title Author Date Type Operation

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverserespiratory events in post anesthesia care unit

Fei Liu, Li Liu, Fang Zheng, Xiangdong Tang, Yongxin Bao, Yunxia Zuo

Journal Article

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Journal Article

Smoothing ramp events in wind farm based on dynamic programming in energy internet

Jiang LI, Guodong LIU, Shuo ZHANG

Journal Article

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Journal Article

The Ejection and Sweep in the Wall Region of a Turbulent Boundary Layer Under Adverse Pressure Gradient

Zhang Qiang,Lu Lipeng

Journal Article

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Journal Article

The effects of festivals and special events on city image design

LIU Yuan, CHEN Chong

Journal Article

Characterization of bacterial communities during persistent fog and haze events in the Qingdao coastal

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article